Stanford University is seeking a Life Science Research Professional 1 to perform basic functions and activities involved in defined research projects, and independently conduct and analyze experiments.
About the Department of Pathology
Comprised of extraordinary faculty and staff, our mission is to improve the diagnosis, treatment and basic understanding of human disease. We accomplish this through our clinical services, research, and training the future leaders in pathology and related fields.
For more information about the department visit http://pathology.stanford.edu/
About the Position
An LSRP position is available in the combined Lab of Dr. Brooke Howitt, Dr. Gregory Bean, Dr. Gregory Charville, and Dr. Alarice Lowe in the Department of Pathology at Stanford University.
This opportunity allows for exposure to and involvement in a number of different research projects. Our lab studies various cancers including gynecologic, breast, gastrointestinal, and soft tissue sarcomas. We seek to understand the molecular underpinnings of human cancers, with the goal of developing new diagnostic, prognostic, and/or predictive biomarkers that can be applied in anatomic pathology clinical practice. Specifically, Dr. Bean’s research interests include the genomes and transcriptomes of special subtypes of breast tumors, including neuroendocrine carcinomas, salivary-like carcinomas, papillary carcinomas and sarcomas, as well as precursor lesions in breast carcinogenesis. Dr. Charville’s research projects involve studying genetic and epigenetic features of various soft tissue sarcomas including rhabdomyosarcoma and Ewing sarcoma. Dr. Howitt studies genetic, epigenetic, and transcriptomic characteristics of fallopian tube lesions, ovarian cancer, gynecologic sarcomas, endometrial carcinomas, and vulvar lesions. Dr. Alarice Lowe applies circulating tumor cell and molecular technology to identify and characterize rare tumor cells found in blood and cytology specimens. The LSRP will be involved in multiple defined research projects and will be responsible for independently conducting experiments and analyzing data with guidance from the PI’s. Specifically, they will be doing molecular profiling (DNA sequencing, RNA sequencing, and methylome profiling) and biomarker analysis on a variety of human cancers. The position also includes lab management tasks such as ordering supplies, maintaining our slide/block/tissue inventory, keeping detailed lab records, and adhering to safety regulations.
We welcome candidates with a growth mindset, interest in a variety of cancer research questions related to molecular underpinnings of disease, and a willingness to take on challenging learning opportunities.
In addition to comparable research compensation, candidates will have the opportunity to learn and to develop their C.V. or resume through research publications and presentations.
- Plan and perform experiments in support of research projects in lab and/or field based on knowledge of scientific theory. Interpret and perform basic analyses of results.
- DNA and RNA extraction from fresh, frozen, and/or formalin fixed paraffin embedded tissue, with subsequent library preparation and massively parallel sequencing (performed at a core facility). Sequencing data generated can be analyzed using existing software programs. Downstream experiments may include designing a targeted sequencing test, in situ hybridization, and/or immunohistochemical biomarker testing.
- Review literature on an ongoing basis to remain current with new procedures and related research.
- Offer suggestions regarding modifications to procedures and protocols in collaboration with graduate post-doctoral individuals.
- Maintain detailed records of experiments and outcomes.
- Contribute to publication of findings as needed. Participate in the preparation of written documents, including procedures, presentations, and proposals.
- Help with general lab maintenance as needed; maintain lab stocks, manage chemical inventory and safety records, and provide general lab support as needed.
- Help orient and train new staff or students.
Qualifications – External
- A bachelor’s degree in biological sciences or a related field.
- Previous experience (preferred) or established knowledge of basic laboratory techniques in molecular biology.
- Strong analytical skills and excellent judgment.
- Ability to work under deadlines with general guidance is essential.
- Must be accurate, efficient, organized and have excellent record keeping abilities.
- Ability to work with team members in a cooperative fashion.
- Excellent communication skills.
Education & Experience (REQUIRED)
Bachelor’s degree in related scientific field.
Knowledge, Skills and Abilities (REQUIRED)
- General understanding of scientific principles. Demonstrated performance to use knowledge and skills when needed.
- Demonstrated ability to apply theoretical knowledge of science principals to problem solve work.
- Ability to maintain detailed records of experiments and outcomes.
- General computer skills and ability to quickly learn and master computer programs, databases, and scientific applications.
- Ability to work under deadlines with general guidance.
- Excellent organizational skills and demonstrated ability to accurately complete detailed work.
Certifications & Licenses
- Frequently stand, walk, twist, bend, stoop, squat, grasp lightly, use fine manipulation, grasp forcefully, perform desk-based computer tasks, use telephone, write by hand, lift, carry, push and pull objects weighing over 40 pounds.
- Occasionally sit, kneel, crawl, reach and work above shoulders, sort and file paperwork or parts.
- Must have correctible vision to perform duties of the job.
- Ability to bend, squat, kneel, stand, reach above shoulder level, and move on hard surfaces for up to eight hours.
- Position may require repetitive motion.
- May require working in close proximity to blood borne pathogens.
- May require work in an environment where animals are used for teaching and research.
- Position may at times require the employee to work with or be in areas where hazardous materials and/or infectious diseases are present.
- Employee must perform tasks that require the use of personal protective equipment, such as safety glasses and shoes, protective clothing and gloves, and possibly a respirator.
- May require extended or unusual work hours based on research requirements and business needs.